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Article Publish Status: FREE
Abstract Title:

Ginsenoside Rd inhibits the expressions of iNOS and COX-2 by suppressing NF-κB in LPS-stimulated RAW264.7 cells and mouse liver.

Abstract Source:

J Ginseng Res. 2013 Mar ;37(1):54-63. PMID: 23717157

Abstract Author(s):

Dae Hyun Kim, Jae Heun Chung, Ji Sung Yoon, Young Mi Ha, Sungjin Bae, Eun Kyeong Lee, Kyung Jin Jung, Min Sun Kim, You Jung Kim, Mi Kyung Kim, Hae Young Chung

Article Affiliation:

Dae Hyun Kim

Abstract:

Ginsenoside Rd is a primary constituent of the ginseng rhizome and has been shown to participate in the regulation of diabetes and in tumor formation. Reports also show that ginsenoside Rd exerts anti-oxidative effects by activating anti-oxidant enzymes. Treatment with ginsenoside Rd decreased nitric oxide and prostaglandin E2 (PGE2) in lipopolysaccharides (LPS)-challenged RAW264.7 cells and in ICR mouse livers (5 mg/kg LPS; LPS + ginsenoside Rd [2, 10, and 50 mg/kg]). Furthermore, these decreases were associated with the down-regulations of inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 and of nuclear factor (NF)-κB activity in vitro and in vivo. Our results indicate that ginsenoside Rd treatment decreases; 1) nitric oxide production (40% inhibition); 2) PGE2 synthesis (69% to 93% inhibition); 3) NF-κB activity; and 4) the NF-κB-regulated expressions of iNOS and COX-2. Taken together, our results suggestthat the anti-inflammatory effects of ginsenoside Rd are due to the down-regulation of NF-κB and the consequent expressional suppressions of iNOS and COX-2.

Study Type : Animal Study, In Vitro Study

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Sayer Ji
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