Ginsenoside Re could be used to improve high fat diet induced insulin resistance. - GreenMedInfo Summary
Ginsenoside Re Ameliorates Brain Insulin Resistance and Cognitive Dysfunction in High-fat Diet-induced C57BL/6 Mice.
J Agric Food Chem. 2017 Mar 17. Epub 2017 Mar 17. PMID: 28314104
Jong Min Kim
The ameliorating effects of ginsenoside Re (G Re) on high-fat diet (HFD)-induced insulin resistance in C57BL/6 mice were investigated to assess its physiological function. In the results of behavioral tests, G Re improved cognitive dysfunction on diabetic mice using Y-maze, passive avoidance and Morris water maze tests. G Re also significantly recovered hyperglycemia and fasting blood glucose level. In the results of serum analysis, G Re decreased triglyceride (TG), total cholesterol (TCHO), low density lipoprotein cholesterol (LDLC), glutamic-oxaloacetic transaminase (GOT) and glutamic-pyruvic transaminase (GPT), and increased the ratio of high density lipoprotein cholesterol (HDLC). G Re regulated the acetylcholine (ACh), acetylcholinesterase (AChE), malondialdehyde (MDA), superoxide dismutase (SOD) and oxidized glutathione (GSH)/total GSH by regulating the c-Jun N-terminal protein kinase (JNK) pathway. These findings suggest that G Re could be used to improve HFD-induced insulin resistance condition by ameliorating hyperglycemia via protecting the cholinergic and antioxidant system in the mice brains.