Antioxidative properties of ginsenoside Ro against UV-B-induced oxidative stress in human dermal fibroblasts.
Biosci Biotechnol Biochem. 2015 ;79(12):2018-21. Epub 2015 Jul 27. PMID: 26214051
Hyun Ji Kang
Ginsenoside Ro (Ro), an oleanolic acid-type ginsenoside, exhibited suppressive activities on reactive oxygen species (ROS) and matrix metalloproteinase-2 (MMP-2) elevation in UV-B-irradiated fibroblasts. Ro could overcome the reduction of the total glutathione (GSH) contents in UV-B-irradiated fibroblasts. Ro could not interfere with cell viabilities in UV-B-irradiated fibroblasts. Collectively, Ro possesses a potential skin anti-photoaging property against UV-B radiation in fibroblasts.