Abstract Title:

The efficacy and safety of gamma-linolenic acid in the treatment of infantile atopic dermatitis.

Abstract Source:

J Int Med Res. 1994 Jan-Feb;22(1):24-32. PMID: 7910570

Abstract Author(s):

A Fiocchi, M Sala, P Signoroni, G Banderali, C Agostoni, E Riva


Full Citation: "The efficacy and safety of gamma-linolenic acid in the treatment of atopic dermatitis was evaluated. The children (mean age, 11.4 months) with atopic dermatitis (mean duration, 8.56 months) were openly treated with 3 g/day gamma-linolenic acid, for 28 days. Clinical evaluations were carried out every 7 days, and parents were asked to keep a diary, recording details of symptoms of eczema every day. Blood chemistry and immunological tests were done before and after treatment. None of the children showed complete recovery of symptoms. A gradual improvement in erythema, excoriations and lichenification was seen; significant differences were shown for itching (P < 0.01), and the use of antihistamines (P < 0.01). A significant rise in the percentage of circulating CD8 was found. No side-effects were recorded. Dietetic and pharmacological approaches are the basis of the treatment of atopic dermatitis and gamma-linolenic acid appears to be a safe and efficient additional therapy for infants and young children."

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