Abstract Title:

Effects ofβ-(1,3-1,6)-d-glucan on irritable bowel syndrome-related colonic hypersensitivity.

Abstract Source:

Biochem Biophys Res Commun. 2012 Mar 10. Epub 2012 Mar 10. PMID: 22430139

Abstract Author(s):

Teita Asano, Ken-Ichiro Tanaka, Shintaro Suemasu, Tomoaki Ishihara, Kayoko Tahara, Toshio Suzuki, Hidekazu Suzuki, Shin Fukudo, Tohru Mizushima

Article Affiliation:

Department of Analytical Chemistry, Faculty of Pharmacy, Keio University, Tokyo 105-8512, Japan.


Irritable bowel syndrome (IBS) is a gastrointestinal disorder characterized by chronic abdominal pain associated with altered bowel habits. Since the prevalence of IBS is very high and thus, involves elevated health-care costs, treatment of this condition by methods other than prescribed medicines could be beneficial.β-(1,3)-d-glucan with β-(1,6) branches (β-glucan) has been used as a nutritional supplement for many years. In this study, we examined the effect of β-glucan on fecal pellet output and visceral pain response in animal models of IBS. Oral administration of β-glucan suppressed the restraint stress- or drug-induced fecal pellet output. β-Glucan also suppressed the visceral pain response to colorectal distension. These results suggest that β-glucan could be beneficial for the treatment and prevention of IBS.

Study Type : Animal Study

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