Article Publish Status: FREE
Abstract Title:

Glucose-lowering activity of dark tea protein extract by modulating spleen-brain axis of diabetic mice.

Abstract Source:

Br J Nutr. 2020 Dec 10:1-29. Epub 2020 Dec 10. PMID: 33298209

Abstract Author(s):

Keying Su, Xinliang Mao, Xuewu Zhang

Article Affiliation:

Keying Su


The present study was to explore the glucose-lowering effects of the previously characterized dark tea (Camellia sinensis L) protein extract (DTPE) from Heimaojian on spleen-brain axis of diabetic mice. DTPE was orally administrated (50-100 mg/kg) to alloxan-induced mice for 21 days, biochemical assay and transcriptome profiling (RNA-Seq) were performed. The results showed that DTPE can improve glucose tolerance. Compared with model group, at day 21, the fasting blood glucose values were significantly (p<0.05) decreased by 44.9% (13.8 vs 7.6 mmol/L) and 51.4% (13.8 vs 6.7 mmol/L) for high dose of DTPE (100 mg/kg) and drug metformin (125 mg/kg) groups, respectively. Subsequently, transcriptome profiling (RNA-Seq) was performed on the spleen and brain of diabetic mice. Totally, 52 spleen-derived and 47 brain-derived differentially expressed genes related to the synthesis, transport and metabolism of glucose were identified. The regulatory network analysis indicated that DTPE may exert glucose-lowering effects through a 37-gene sub-network related to metabolism, Parkinson's disease, oxidative phosphorylation and immunity. In summary, for the first time, the present data revealed that dark tea-derived DTPE could exert a potential anti-hyperglycemic effect by modulating spleen-brain axis.

Study Type : Animal Study

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.