Glycyrrhiza glabra suppresses nasopharyngeal carcinoma cell proliferation. - GreenMedInfo Summary
suppresses nasopharyngeal carcinoma cell proliferation through inhibiting the expression of lncRNA, AK027294.
Biosci Biotechnol Biochem. 2019 Oct 7:1-7. Epub 2019 Oct 7. PMID: 31589096
is considered as potential drug for nasopharyngeal carcinoma (NPC). However, whether the long noncoding RNAs' (lncRNAs) contributes to the anti-cancer function of this herb is unknown. In present study, we analyzed the differential expression of lncRNA between-treated and untreated C666-1 cells. Out of those tumor-related lncRNAs, AK027294 had a strongest down-regulation upontreatment. Knockdown of AK027294 suppresses the proliferation of C666-1 cells by inducing the apoptosis. Moreover, eithertreatment or knockdown of AK027294 significantly increases the production of EZH1 (Enhancer of zeste 1 polycomb repressive complex 2 subunit). Collectively, we have identified a potential mechanism that the down-regulation of AK027294 contributes to the anti-cancer function ofand also provide the potential inter-relationship between AK027294 and EZH1.