Abstract Title:

suppresses nasopharyngeal carcinoma cell proliferation through inhibiting the expression of lncRNA, AK027294.

Abstract Source:

Biosci Biotechnol Biochem. 2019 Oct 7:1-7. Epub 2019 Oct 7. PMID: 31589096

Abstract Author(s):

Bo Zhang, Min Yan, Wei Zhang, Zhao-Yang Ke, Ling-Guo Ma

Article Affiliation:

Bo Zhang


is considered as potential drug for nasopharyngeal carcinoma (NPC). However, whether the long noncoding RNAs' (lncRNAs) contributes to the anti-cancer function of this herb is unknown. In present study, we analyzed the differential expression of lncRNA between-treated and untreated C666-1 cells. Out of those tumor-related lncRNAs, AK027294 had a strongest down-regulation upontreatment. Knockdown of AK027294 suppresses the proliferation of C666-1 cells by inducing the apoptosis. Moreover, eithertreatment or knockdown of AK027294 significantly increases the production of EZH1 (Enhancer of zeste 1 polycomb repressive complex 2 subunit). Collectively, we have identified a potential mechanism that the down-regulation of AK027294 contributes to the anti-cancer function ofand also provide the potential inter-relationship between AK027294 and EZH1.

Study Type : In Vitro Study

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