Abstract Title:

Glycyrrhiza uralensis root extract ameliorates high glucose-induced renal proximal tubular fibrosis by attenuating tubular epithelial-myofibroblast transdifferentiation by targeting TGF-β1/Smad/Stat3 pathway.

Abstract Source:

J Food Biochem. 2022 Jan 21:e14041. Epub 2022 Jan 21. PMID: 35064587

Abstract Author(s):

Henry Cherng-Han Lin, Catherine Reena Paul, Chia-Hua Kuo, Yung-Hsien Chang, William Shao-Tsu Chen, Tsung-Jung Ho, Cecilia-Hsuan Day, Bharath Kumar Velmurugan, Yuhsin Tsai, Chih-Yang Huang

Article Affiliation:

Henry Cherng-Han Lin


Growing evidences indicate that high glucose toxicity-associated fibrotic effects play a pivotal role in diabetic nephropathy (DN). Tubular epithelial-myofibroblast transdifferentiation is a major hallmark of renal fibrosis event under diabetic stress. Roots of Glycyrrhiza uralensis (Radix glycyrrhizae) used as a sweetener and traditional Chinese medicine possess high potential for renal protection. In this study, a cell model for high glucose (HG) injury with HK-2 renal proximal tubular epithelial cell line and a type-II-diabetes model with Apoe/Narl mice was established and the beneficial effects of aqueous R. glycyrrhizae extract (RGE) was investigated. RGE-induced regulation on the high glucose-induced excessive production of TGF-β1 and the Smad/Stat3 mechanisms of renal fibrosis were determined. HK-2 cells were challenged with 45 mM of high glucose for 48 hr. Following high glucose challenge, the cells were treated with 0.5, 1, and 1.5 mg/ml concentrations of RGE. The effect of RGE on DN was determined using high fructose diet-induced type-II-diabetes in Apoe/Narl mice models. Our results showed that RGE suppressed the expression of HG-induced TGFβ signaling and associated fibrosis mechanism better than the pharmacological drug acarbose. These data suggest that RGE as a potential herbal supplement in attenuating fibrosis-associated diabetic nephropathy and a potential agent in diabetes treatments.

Study Type : In Vitro Study

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