Abstract Title:

Glycyrrhizic acid prevents astrocyte death by neuromyelitis optica-specific IgG via inhibition of C1q binding.

Abstract Source:

Biochem Biophys Res Commun. 2016 Jul 25. Epub 2016 Jul 25. PMID: 27462020

Abstract Author(s):

Ji-Sun Kim, Soyoung Cheon, Seung Woo Kim, Boram Kim, Heejaung Kim, Ki Duk Park, Sung-Min Kim

Article Affiliation:

Ji-Sun Kim


Neuromyelitis optica (NMO) is an inflammatory demyelinating disease of the central nervous system and is mediated by complement-dependent cytotoxicity (CDC) of NMO-specific immunoglobulin G (IgG) antibodies (NMO-IgG). Glycyrrhizic acid (GA) has numerous pharmacological effects including inhibition of the complement pathway. We aimed to study the influence of GA on NMO-IgG-induced CDC. NMO-IgG samples from 7 patients with NMO, together with human complement, induced CDC in an aquaporin 4 M23-overexpressing glial cell line, an in vitro NMO model. GA attenuated NMO-IgG-induced CDC in a dose-dependent manner. The mechanism of the GA-related CDC inhibition was sequentially dissected and found to involve inhibition of C1q binding to NMO-IgG. Consequently, GA attenuates NMO-IgG-induced CDC and may be a promising novel therapeutic agent against NMO.

Study Type : Human In Vitro
Additional Links
Pharmacological Actions : Immunomodulatory : CK(4048) : AC(1475)

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