Abstract Title:

Effects of glyphosate on cholinesterase activity of the mussel Perna perna and the fish Danio rerio and Jenynsia multidentata: in vitro studies.

Abstract Source:

Aquat Toxicol. 2013 Apr 15 ;130-131:171-3. Epub 2013 Jan 18. PMID: 23411353

Abstract Author(s):

Juliana Zomer Sandrini, Regina Coimbra Rola, Fernanda Moreira Lopes, Hermeson Francisco Buffon, Milene Marques Freitas, Camila de Martinez Gaspar Martins, Carlos Eduardo da Rosa

Article Affiliation:

Instituto de Ciências Biológicas, Universidade Federal do Rio Grande, Rio Grande, RS, Brazil. [email protected]


Although the herbicide glyphosate [N-(phosphonomethyl)glycine] is not classified as an acethylcholinesterase inhibitor, some studies have reported reduction in the acethylcolinesterase activity after in vivo exposure to both its pure form and its commercial formulations. Considering this controversy, the objective of the present study was to investigate, in vitro, the effects of glyphosate exposure on cholinesterase activity of the brown mussel Perna perna and of two fish species: zebrafish Danio rerio and onesided livebearer Jenynsia multidentata. For this purpose, samples of different tissues (brain and muscle for fish; gills and muscle for mussel) were homogenized and pre-incubated with different glyphosate concentrations before cholinesterase activity determination. Results demonstrated that cholinesterase from different fractions of all species tested was inhibited by glyphosate. The concentrations of glyphosate that inhibits 50% of cholinesterase activity (IC50) ranged from 0.62 mM for P. perna muscle to 8.43 mM for J. multidentata brain. According to this, cholinesterase from mussel seems to be more sensitive to glyphosate exposure than those from the fish D. rerio and J. multidentata.

Study Type : Animal Study
Additional Links
Problem Substances : Glyphosate : CK(895) : AC(304)

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