Abstract Title:

Cytogenetic effect of technical glyphosate on cultivated bovine peripheral lymphocytes.

Abstract Source:

Int J Hyg Environ Health. 2006 Jan ;209(1):15-20. Epub 2005 Aug 29. PMID: 16373198

Abstract Author(s):

Katarína Siviková, Ján Dianovskỳ

Article Affiliation:

Institute of Genetics, University of Veterinary Medicine, Komenského 73, 041 81 Kosice, Slovak Republic. [email protected]


A technical herbicide containing isopropyl amine salt of glyphosate was tested for induction of chromosome aberrations (CA) and sister chromatid exchanges (SCE) in cultured bovine peripheral lymphocytes. Cultures were exposed to a glyphosate formulation at concentrations ranging from 28 to 1120 micromol/l without and with metabolic activation. No clastogenic effect of the herbicide was found. Its genotoxic effect was confirmed in the SCE assay after 24 h of incubation. A statistically significant elevation in SCE induction was observed in each of the donors after application of the product at doses ranging from 56 to 1120 micromol/l. The highest concentrations (560 and 1120 micromol/l) also caused reduction of mitotic and proliferation indices. In the 2 h-assay with metabolic activation a statistically significant frequency of SCE was observed only in cultures treated with the agent at a concentration of 140 micromol/l.

Study Type : In Vitro Study
Additional Links
Problem Substances : Glyphosate : CK(895) : AC(304)
Adverse Pharmacological Actions : Genotoxic : CK(540) : AC(179)

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.