Article Publish Status: FREE
Abstract Title:

Gold nanoparticle hyperthermia reduces radiotherapy dose.

Abstract Source:

Nanomedicine. 2014 Nov ;10(8):1609-17. Epub 2014 Jun 3. PMID: 24990355

Abstract Author(s):

James F Hainfeld, Lynn Lin, Daniel N Slatkin, F Avraham Dilmanian, Timothy M Vadas, Henry M Smilowitz

Article Affiliation:

James F Hainfeld


UNLABELLED: Gold nanoparticles can absorb near infrared light, resulting in heating and ablation of tumors. Gold nanoparticles have also been used for enhancing the X-ray dose to tumors. The combination of hyperthermia and radiotherapy is synergistic, importantly allowing a reduction in X-ray dose with improved therapeutic results. Here we intratumorally infused small 15 nm gold nanoparticles engineered to be transformed from infrared-transparent to infrared-absorptive by the tumor, then heated by infrared followed by X-ray treatment. Synergy was studied using a very radioresistant subcutaneous squamous cell carcinoma (SCCVII) in mice. It was found that the dose required to control 50% of the tumors, normally 55 Gy, could be reduced to<15 Gy (a factor of>3.7). Gold nanoparticles therefore provide a method to combine hyperthermia and radiotherapy to drastically reduce the X-ray radiation needed, thus sparing normal tissue, reducing side effects, and making radiotherapy more effective.

FROM THE CLINICAL EDITOR: Gold nanoparticles are known to enhance the efficacy of X-ray in tumor irradiation resulting in tumor heating and ablation. They also absorb near infrared light. This dual property was studied using a very radioresistant subcutaneous squamous cell carcinoma in mice, demonstrating that the dose required to control 50% of the tumors could be reduced by a factor of>3.7, paving the way to potential future clinical applications.

Study Type : Animal Study

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