Article Publish Status: FREE
Abstract Title:

Gold nanoparticles and radiofrequency in experimental models for hepatocellular carcinoma.

Abstract Source:

Nanomedicine. 2014 Aug ;10(6):1121-30. Epub 2014 Mar 17. PMID: 24650884

Abstract Author(s):

Mustafa Raoof, Stuart J Corr, Cihui Zhu, Brandon T Cisneros, Warna D Kaluarachchi, Sophia Phounsavath, Lon J Wilson, Steven A Curley

Article Affiliation:

Mustafa Raoof


UNLABELLED: Hepatocellular carcinoma (HCC) is one of the most lethal and chemo-refractory cancers, clearly, alternative treatment strategies are needed. We utilized 10nm gold nanoparticles as a scaffold to synthesize nanoconjugates bearing a targeting antibody (cetuximab, C225) and gemcitabine. Loading efficiency of gemcitabine on the gold nanoconjugates was 30%. Targeted gold nanoconjugates in combination with RF were selectively cytotoxic to EGFR expressing Hep3B and SNU449 cells when compared to isotype particles with/without RF (P<0.05). In animal experiments, targeted gold nanoconjugates halted the growth of subcutaneous Hep3B xenografts in combination with RF exposure (P<0.05). These xenografts also demonstrated increased apoptosis, necrosis and decreased proliferation compared to controls. Normal tissues were unharmed. We have demonstrated that non-invasive RF-induced hyperthermia when combined with targeted delivery of gemcitabine is more effective and safe at dosages ~275-fold lower than the current clinically-delivered systemic dose of gemcitabine.

FROM THE CLINICAL EDITOR: In a model of hepatocellular carcinoma, the authors demonstrate that non-invasive RF-induced hyperthermia applied with cetuximab targeted delivery of Au NP-gemcitabine conjugate is more effective and safe at dosages ~ 275-fold lower than the current clinically-used systemic dose of gemcitabine.

Study Type : In Vitro Study

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