Graviola (Annona muricata) contains compounds with cytotoxic effects against prostate and pancreatic cancer cell lines. - GreenMedInfo Summary

Abstract Title:

Muricoreacin and murihexocin C, mono-tetrahydrofuran acetogenins, from the leaves of Annona muricata.

Abstract Source:

Phytochemistry.1998 Sep;49(2):565-71. PMID: 9747542

Abstract Author(s):

G S Kim, L Zeng, F Alali, L L Rogers, F E Wu, S Sastrodihardjo, J L McLaughlin

Abstract:

Bioactivity-directed fractionation of the leaves of Annona muricata L. (Annonaceae) resulted in the isolation of two new Annonaceous acetogenins, muricoreacin (1) and murihexocin C (2). Compounds 1 and 2 showed significant cytotoxicities among six human tumor cell lines with selectivities to the prostate adenocarcinoma (PC-3) and pancreatic carcinoma (PACA-2) cell lines.

Article Published Date : Sep 01, 1998
Study Type : In Vitro Study
Additional Links
Substances : Graviola : CK(76) : AC(40)
Diseases : Pancreatic Cancer : CK(1547) : AC(564), Prostate Cancer : CK(2805) : AC(1046)

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Key Research Topics

Disease

Pancreatic Cancer
Prostate Cancer

Substance

Graviola

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