Article Publish Status: FREE
Abstract Title:

Antiulcerogenic activity of the hydroalcoholic extract of leaves ofLinnaeus in mice.

Abstract Source:

Saudi J Biol Sci. 2018 May ;25(4):609-621. Epub 2016 Jan 21. PMID: 29736140

Abstract Author(s):

Elizângela Beneval Bento, Francisco Elizaudo de Brito Júnior, Dayanne Rakelly de Oliveira, Cícera Norma Fernandes, Gyllyandeson de Araújo Delmondes, Francisco Rafael Alves Santana Cesário, Cristina Kelly de Sousa Rodrigues, Valterlúcio Dos Santos Sales, Francisco Rodolpho Sobreira Dantas Nóbrega de Figueiredo, Izabel Cristina Santiago Lemos, Álefe Brito Monteiro, Irwin Rose Alencar de Menezes, José Galberto Martins da Costa, Marta Regina Kerntopf

Article Affiliation:

Elizângela Beneval Bento


Linnaeus, popularly known as"graviola"and also called soursop, is a species typical of countries with a tropical climate, and it is used in folk medicine as an anticancer, analgesic and antispasmodic agent. The aim of the present study was to validate the gastroprotective activity of the hydroalcoholic extract of the leaves of(HEAM) and to investigate the underlying mechanisms of action for this effect. Gastric lesions were induced in mice by absolute ethanol, acidified ethanol or indomethacin. Before, the animals were pretreated with saline, omeprazole or HEAM orally at doses of 50-400 mg/kg. To determine the mechanism of action of the extract, we investigated, using specific inhibitors, the involvement of nitric oxide (NO), prostaglandins (PGEs), ATP-dependent Kchannels andα2-noradrenergic receptors. HEAM showed significant antiulcer activity against lesions induced by absolute ethanol, acidified ethanol or indomethacin, which was mediated by endogenous gastric prostaglandins.

Study Type : Animal Study
Additional Links
Pharmacological Actions : Anti-Ulcer Agents : CK(523) : AC(184)

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