Abstract Title:

Effects of chronic ingestion of catechin-rich green tea on hepatic gene expression of gluconeogenic enzymes in rats.

Abstract Source:

Biomed Res.2009 Feb;30(1):25-9. PMID: 19265260

Abstract Author(s):

Koichi Abe, Norihisa Okada, Hiroki Tanabe, Ryuuta Fukutomi, Kensuke Yasui, Mamoru Isemura, Naohide Kinae


Normal rats were given catechin-rich green tea as drinking fluid and the effects on hepatic gene expression were examined. The results of DNA microarray analysis and quantitative real-time reverse transcription-polymerase chain reaction indicated the down-regulated expression of genes for glucose-6-phosphatase (G6Pase) and fatty acid synthase, and the up-regulated expression of peroxisome proliferator activated receptor alpha in the rats given green tea for 4 weeks as compared with the water-given animals. One may expect anti-diabetic activity by catechin-rich green tea through its chronic down-regulatory effect on G6Pase expression.

Study Type : Animal Study

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Sayer Ji
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