Abstract Title:

Green tea may be benefit to the therapy of atrial fibrillation.

Abstract Source:

J Cell Biochem. 2011 Mar 4. Epub 2011 Mar 4. PMID: 21381081

Abstract Author(s):

Xin Zeng, Qiao Li, Miao Zhang, Wei Wang, Xuerui Tan

Article Affiliation:

Department of Cardiology, The First Affiliated Hospital of Shantou University Medical College, Shantou 515041, Peoples' Republic of China.


Atrial fibrillation (AF) is the most common cardiac arrhythmia in clinical practice. Systemic inflammatory state, oxidative stress injury and atrial fibrosis are identified as the main mechanisms for atrial fibrillation. Considering the multifactorial mechanisms of AF, a novel therapeutic agent with multi-bioactivities should be presented. Regular consumption of green tea has been associated with a reduced risk of coronary heart disease and against a large number of pathologic conditions. Recent results indicate that green tea extract(GTE), especially (-)-epigallocatechin-3-gallate (EGCg), could effectively decrease inflammatory factors secretion, antagonize oxidation, and inhibit matrix metalloproteinase(MMP) activities. Inhibition of inflammation, modulation of oxidative stress and targeting tissue fibrosis represent new approaches in tackling AF, therefore green tea may be an innovative therapeutic candidate to prevent the occurrence, maintenance and recurrence of AF. J. Cell. Biochem.© 2011 Wiley-Liss, Inc.

Study Type : Review

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