Article Publish Status: FREE
Abstract Title:

Green tea polyphenols protect spinal cord neurons against hydrogen peroxide-induced oxidative stress.

Abstract Source:

Neural Regen Res. 2014 Jul 15 ;9(14):1379-85. PMID: 25221595

Abstract Author(s):

Jianbo Zhao, Shiqiang Fang, Yajiang Yuan, Zhanpeng Guo, Jinhao Zeng, Yue Guo, Peifu Tang, Xifan Mei

Article Affiliation:

Jianbo Zhao


Green tea polyphenols are strong antioxidants and can reduce free radical damage. To investigate their neuroprotective potential, we induced oxidative damage in spinal cord neurons using hydrogen peroxide, and applied different concentrations (50-200μg/mL) of green tea polyphenol to the cell medium for 24 hours. Measurements of superoxide dismutase activity, malondialdehyde content, and expression of apoptosis-related genes and proteins revealed that green tea polyphenol effectively alleviated oxidative stress. Our results indicate that greentea polyphenols play a protective role in spinal cord neurons under oxidative stress.

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