Green tea protects against asbestos-induced cell injury. - GreenMedInfo Summary

Abstract Title:

Protective effects of green tea catechins against asbestos-induced cell injury.

Abstract Source:

Planta Med. 2000 Dec;66(8):762-4. PMID: 11199139

Abstract Author(s):

V A Kostyuk, A I Potapovich, E N Vladykovskaya, M Hiramatsu

Abstract:

Green tea extract was found to provide a strong protective effect against asbestos-induced injury of peritoneal macrophages and red blood cells in vitro. The main polyphenolic constituents of green tea extract, (-)-epicatechin gallate (ECG) and (-)-epigallocatechin gallate (EGCG), were also efficient in preventing injury of cells following exposure to asbestos fibers. The protective efficacies of EGCG and ECG expressed as IC50 values were, respectively, 10 microM and 12 microM if peritoneal macrophages were injured by chrysotile and 4 microM and 5 microM in the case of crocidolite-induced cell injury. Antiradical and chelating properties of ECG and EGCG were evaluated and it was concluded that the protective effect of catechins against asbestos-induced injury may be related to both scavenger properties towards to superoxide anion and the ability to chelate iron ions.

Article Published Date : Dec 01, 2000
Study Type : In Vitro Study
Additional Links
Substances : Catechin : CK(986) : AC(314), EGCG (Epigallocatechin gallate) : CK(1592) : AC(824), Green Tea : CK(4499) : AC(1387)
Diseases : Asbestos Toxicity : CK(15) : AC(5)

Print Options

Some features are currently member only features. If you are already a member, please login. Otherwise, click here to become a member.
  • Printer-friendly version

Key Research Topics

Substance

EGCG (Epigallocatechin gallate)
Green Tea
Catechin

Disease

Asbestos Toxicity

Connect with GreenMedInfo