Article Publish Status: FREE
Abstract Title:

Guarana () Extract ProtectsModels for Alzheimer Disease and Huntington Disease through Activation of Antioxidant and Protein Degradation Pathways.

Abstract Source:

Oxid Med Cell Longev. 2018 ;2018:9241308. Epub 2018 Jul 4. PMID: 30116496

Abstract Author(s):

Patrícia Ferreira Boasquívis, Giovanna Melo Martins Silva, Franciny Aparecida Paiva, Rodrigo Marinho Cavalcanti, Cecília Verônica Nunez, Riva de Paula Oliveira

Article Affiliation:

Patrícia Ferreira Boasquívis


Guarana () is largely consumed in Brazil in high energy drinks and dietary supplements because of its stimulant activity on the central nervous system. Although previous studies have indicated that guarana has some protective effects in Parkinson's (PD), Alzheimer's (AD), and Huntington's (HD) disease models, the underlying mechanisms are unknown. Here, we investigated the protective effects of guarana hydroalcoholic extract (GHE) inmodels of HD and AD. GHE reduced polyglutamine (polyQ) protein aggregation in the muscle and also reduced polyQ-mediated neuronal death in ASH sensory neurons and delayed-amyloid-induced paralysis in a caffeine-independent manner. Moreover, GHE's protective effects were not mediated by caloric restriction, antimicrobial effects, or development and reproduction impairment. Inactivation of the transcription factors SKN-1 and DAF-16 by RNAi partially blocked the protective effects of GHE treatment in the AD model. We show that the protective effect of GHE is associated with antioxidant activity and modulation of proteostasis, since it increased the lifespan and proteasome activity, reduced intracellular ROS and the accumulation of autophagosomes, and increased the expression of SOD-3 and HSP-16.2. Our findings suggest that GHE has therapeutic potential in combating age-related diseases associated with protein misfolding and accumulation.

Study Type : Animal Study

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