Abstract Title:

Evaluation of the Efficacy of Guava Extract as an Antimicrobial Agent on Periodontal Pathogens.

Abstract Source:

J Contemp Dent Pract. 2018 Jun 1 ;19(6):690-697. Epub 2018 Jun 1. PMID: 29959298

Abstract Author(s):

Y Sunaina Shetty, Rajesh Shankarapillai, Gopinath Vivekanandan, Raghavendra M Shetty, Challa S Reddy, Hanumanth Reddy, Sachin B Mangalekar

Article Affiliation:

Y Sunaina Shetty


AIM: The present study was undertaken to assess the inhibitory effect of guava extracts on Porphyromonas gingivalis and Aggregatibacteractinomycetemcomitans, to assess the time-kill curve of P. gingivalis and A. actinomycetemcomitans, and to determine the antiproteolytic activity of guava on P. gingivalis.

MATERIALS AND METHODS: Kanamycin blood agar was used to isolate P. gingivalis and A. actinomycetemcomitans. Ethanolic guava extract (EGE) and aqueous guava extract (AGE) were prepared and the inhibitory effects of these extracts for two periodontal pathogens were tested by minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) procedures. Antibacterial activity of guava extracts was determined by well diffusion method. Antiproteolytic activity of guava on protease of P. gingivalis was determined by gelatin liquefaction test.

RESULTS: The MIC determined for AGE and EGE was at 75μL/mL concentration for P. gingivalis, whereas EGE exhibited the activity at 75 μL/mL on P. gingivalis. The MIC determined for AGE was at 50 μL/mL for A. actinomycetemcomitans, whereas MIC determined for EGE was at 3.12 μL/mL for A. actinomycetemcomitans. Porphyromonas gingivalis was susceptibleto EGE compared with AGE. Aggregatibacter actinomycetemcomitans was more susceptible to guava extracts compared with P. gingivalis.

CONCLUSION: Guava extract may be a potential therapeutic agent for periodontitis as it shows significant activity against both P. gingivalis and A. actinomycetemcomitans.

CLINICAL SIGNIFICANCE: Guava leaves extract can be used as economical and suitable adjuvant to synthetic drugs and can be a potential therapeutic agent for periodontitis.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Antimicrobial : CK(1209) : AC(582)

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & receive The Dark Side of Wheat Ebook

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

The Dark Side of Wheat

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2023 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.