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Abstract Title:

exerts hypoglycemic effects on streptozotocin-induced diabetic ratsmodulating,,andgene expression.

Abstract Source:

J Diabetes Metab Disord. 2020 Jun ;19(1):483-491. Epub 2020 May 11. PMID: 32550200

Abstract Author(s):

Rehab M Abdel-Megeed, Samah A El Newary, Mai O Kadry, Hassan Z Ghanem, Rabeh A El-Shesheny, Hussein A H Said-Al Ahl, Abdel-Hamid Z Abdel-Hamid

Article Affiliation:

Rehab M Abdel-Megeed

Abstract:

Objectives: Type 2 diabetes mellitus (DMT2) is contributed to dual interactions between environmental factors and certain genetic factors. This impressed a great need for novel treatment strategy. Nevertheless,(as a terrestrial herb is considered to be an important source of natural antioxidants, it could be assessed as an anti-hyperglycemic agent.

Methods: In the current study, HPLC identified the active constitutes of, including total polyphenols, and flavonoids. Type 2 diabetes mellitus was induced in male Wistar albino ratsa singledose of streptozotocin (STZ) (35 mg/kg BW). One week post diabetes induction, rats were administrated(500 mg/ kg BW) orally for one month. Molecular analysis was assessed to investigate the efficiency ofon modulating ATP-binding cassette transporter A1 () and G1 () genes, in addition to apoptotic biomarkers, glycogen synthase kinase-3β () and cellular oncogene-fos () genes. Furthermore, inflammatory biomarkers, nuclear factor kappa-B () and tumor necrosis factor-α () gene expression were also assessed.

Results: alcoholic extract declared the presence of polyphenols as gallic acid and flavonoids as quercetin in addition to many active constituents. Apigenin-7-glucoside and Chlorgenic acid were the most common constituents in the extract. RT-PCR results declared a significant up-regulation in mRNA gene expression ofandupontreatment. Meanwhile,gene expression recorded a slight down-regulation. Gene expression of apoptotic biomarkerdemonstrated a significant down regulation as well as inflammatory biomarkersand.

Conclusion: From the data recorded, it could be concluded thatexerts a great hypoglycemic potential via modulating,,andgene expression and signaling pathways and could be considered as an effective candidate for DMT2 treatment.

Study Type : Animal Study

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