Abstract Title:

exerts hypoglycemic effects on streptozotocin-induced diabetic ratsmodulating,,andgene expression.

Abstract Source:

J Diabetes Metab Disord. 2020 Jun ;19(1):483-491. Epub 2020 May 11. PMID: 32550200

Abstract Author(s):

Rehab M Abdel-Megeed, Samah A El Newary, Mai O Kadry, Hassan Z Ghanem, Rabeh A El-Shesheny, Hussein A H Said-Al Ahl, Abdel-Hamid Z Abdel-Hamid

Article Affiliation:

Rehab M Abdel-Megeed


Objectives: Type 2 diabetes mellitus (DMT2) is contributed to dual interactions between environmental factors and certain genetic factors. This impressed a great need for novel treatment strategy. Nevertheless,(as a terrestrial herb is considered to be an important source of natural antioxidants, it could be assessed as an anti-hyperglycemic agent.

Methods: In the current study, HPLC identified the active constitutes of, including total polyphenols, and flavonoids. Type 2 diabetes mellitus was induced in male Wistar albino ratsa singledose of streptozotocin (STZ) (35 mg/kg BW). One week post diabetes induction, rats were administrated(500 mg/ kg BW) orally for one month. Molecular analysis was assessed to investigate the efficiency ofon modulating ATP-binding cassette transporter A1 () and G1 () genes, in addition to apoptotic biomarkers, glycogen synthase kinase-3β () and cellular oncogene-fos () genes. Furthermore, inflammatory biomarkers, nuclear factor kappa-B () and tumor necrosis factor-α () gene expression were also assessed.

Results: alcoholic extract declared the presence of polyphenols as gallic acid and flavonoids as quercetin in addition to many active constituents. Apigenin-7-glucoside and Chlorgenic acid were the most common constituents in the extract. RT-PCR results declared a significant up-regulation in mRNA gene expression ofandupontreatment. Meanwhile,gene expression recorded a slight down-regulation. Gene expression of apoptotic biomarkerdemonstrated a significant down regulation as well as inflammatory biomarkersand.

Conclusion: From the data recorded, it could be concluded thatexerts a great hypoglycemic potential via modulating,,andgene expression and signaling pathways and could be considered as an effective candidate for DMT2 treatment.

Study Type : Animal Study

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2023 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.