Article Publish Status: FREE
Abstract Title:

Hibiscus sabdariffa extract lowers blood pressure and improves endothelial function.

Abstract Source:

Mol Nutr Food Res. 2014 Jun ;58(6):1374-8. Epub 2014 Feb 24. PMID: 24668839

Abstract Author(s):

Jorge Joven, Isabel March, Eugenia Espinel, Salvador Fernández-Arroyo, Esther Rodríguez-Gallego, Gerard Aragonès, Raúl Beltrán-Debón, Carlos Alonso-Villaverde, Lidia Rios, Vicente Martin-Paredero, Javier A Menendez, Vicente Micol, Antonio Segura-Carretero, Jordi Camps

Article Affiliation:

Jorge Joven


Polyphenols from Hibiscus sabdariffa calices were administered to patients with metabolic syndrome (125 mg/kg/day for 4 wk, n = 31) and spontaneously hypertensive rats (125 or 60 mg/kg in a single dose or daily for 1 wk, n = 8 for each experimental group). The H. sabdariffa extract improved metabolism, displayed potent anti-inflammatory and antioxidant activities, and significantly reduced blood pressure in both humans and rats. Diuresis and inhibition of the angiotensin I-converting enzyme were found to be less important mechanisms than those related to the antioxidant, anti-inflammatory, and endothelium-dependent effects to explain the beneficial actions. Notably, polyphenols induced a favorable endothelial response that should be considered in the management of metabolic cardiovascular risks.

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