Abstract Title:

Effects of Psilocybe argentipes on marble-burying behavior in mice.

Abstract Source:

Biosci Biotechnol Biochem. 2009 Aug;73(8):1866-8. Epub 2009 Aug 7. PMID: 19661714

Abstract Author(s):

Yoshihiro Matsushima, Osamu Shirota, Ruri Kikura-Hanajiri, Yukihiro Goda, Fumio Eguchi

Article Affiliation:

Department of Health and Nutrition, Takasaki University of Health and Welfare, Gunma, Japan.


Psilocybe argentipes is a hallucinogenic mushroom. The present study examined the effects of P. argentipes on marble-burying behavior, which is considered an animal model of obsessive-compulsive disorder. P. argentipes significantly inhibited marble-burying behavior without affecting locomotor activity as compared with the same dose of authentic psilocybin. These findings suggest that P. argentipes would be efficient in clinical obsessive-compulsive disorder therapy.

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