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Abstract Title:

Harmine is an effective therapeutic small molecule for the treatment of cardiac hypertrophy.

Abstract Source:

Acta Pharmacol Sin. 2021 Mar 30. Epub 2021 Mar 30. PMID: 33785860

Abstract Author(s):

Jie Huang, Yang Liu, Jia-Xin Chen, Xin-Ya Lu, Wen-Jia Zhu, Le Qin, Zi-Xuan Xun, Qiu-Yi Zheng, Er-Min Li, Ning Sun, Chen Xu, Hai-Yan Chen

Article Affiliation:

Jie Huang

Abstract:

Harmine is aβ-carboline alkaloid isolated from Banisteria caapi and Peganum harmala L with various pharmacological activities, including antioxidant, anti-inflammatory, antitumor, anti-depressant, and anti-leishmanial capabilities. Nevertheless, the pharmacological effect of harmine on cardiomyocytes and heartmuscle has not been reported. Here we found a protective effect of harmine on cardiac hypertrophy in spontaneously hypertensive rats in vivo. Further, harmine could inhibit the phenotypes of norepinephrine-induced hypertrophy in human embryonic stem cell-derived cardiomyocytes in vitro. It reducedthe enlarged cell surface area, reversed the increased calcium handling and contractility, and downregulated expression of hypertrophy-related genes in norepinephrine-induced hypertrophy of human cardiomyocytes derived from embryonic stem cells. We further showed that one of the potential underlyingmechanism by which harmine alleviates cardiac hypertrophy relied on inhibition of NF-κB phosphorylation and the stimulated inflammatory cytokines in pathological ventricular remodeling. Our data suggest that harmine is a promising therapeutic agent for cardiac hypertrophy independent of blood pressure modulation and could be a promising addition of current medications for cardiac hypertrophy.

Study Type : Animal Study

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