Hepatic protective effects of sulforaphane through the modulation of inflammatory pathways. - GreenMedInfo Summary
Hepatic protective effects of sulforaphane through the modulation of inflammatory pathways.
J Asian Nat Prod Res. 2020 Apr ;22(4):386-396. Epub 2019 Mar 1. PMID: 30821482
The aim of this study was to investigate the effects of sulforaphane (SFN) on lipopolysaccharide (LPS)-induced liver failure, and to elucidate underlying mechanisms. SFN, a natural isothiocyanate present in cruciferous vegetables such as broccoli and cabbage, is effective in preventing carcinogenesis, diabetes, and inflammatory responses. Mice were treated intravenously with SFN at 12 h after LPS treatment. LPS significantly increased mortality, serum levels of liver damage markers, and inflammatory cytokines, and toll-like receptor 4 (TLR4) protein expression, which were reduced by SFN. Our results suggest that SFN protects against LPS-induced liver damage, indicating its potential to treat liver diseases.