Hepatoprotection of Mentha aquatica L., Lavandula dentata L. and Leonurus cardiaca L. - GreenMedInfo Summary

The phenolic composition of hydroethanolic extracts ofL.,L. andL., obtained from plants grown under organic cultivation, was determined and their hepatoprotective effects were investigated in vitro.extract was rich in phenylethenoid glycosides, especially lavandolifolioside (254± 36 μg/mg), whereas rosmarinic acid and eriodictyol--rutinoside were the major phenolic compounds ofandextracts, accounting for 68± 7 μg/mg and 145 ± 22 μg/mg, respectively. These differential phenolic components presumably account for their dissimilar antioxidant properties. Whileextract showed moderate biological effects,extract displayed high antioxidant activity in chemical models, and that ofwas effective in counteracting potassium dichromate-induced ROS generation in human hepatocarcinoma cells. Moreover,extract (50μg/mL) and its mixture (50%/50%) withextract displayed an effective cytoprotective effect.