Abstract Title:

Herbal formulation"turmeric extract, black pepper, and ginger"versus Naproxen for chronic knee osteoarthritis: A randomized, double-blind, controlled clinical trial.

Abstract Source:

Phytother Res. 2020 Aug ;34(8):2067-2073. Epub 2020 Mar 16. PMID: 32180294

Abstract Author(s):

Motahar Heidari-Beni, Amir R Moravejolahkami, Pegah Gorgian, Gholamreza Askari, Mohammad J Tarrahi, Nimah Bahreini-Esfahani

Article Affiliation:

Motahar Heidari-Beni


Osteoarthritis is the most common articular disease that can lead to chronic pain and severe disability. Curcumin-an effective ingredient in turmeric with anti inflammatory property-plays an important role in protecting the joints against destructive factors. Gingerols and piperine, are the effective ingredients of ginger and black pepper, which may potentially enhance and sustain the effect of curcumin in this direction. To determine the effect of cosupplementation with turmeric extract, black pepper, and ginger on prostaglandin E(PGE) in patients with chronic knee osteoarthritis, compared with Naproxen. Sixty patients with two different levels of knee osteoarthritis (Grade 2 and 3) were studied. Individuals were randomly assigned to receive daily turmeric extract, ginger, and black pepper together or Naproxen capsule for 4 weeks. PGEwas evaluated by ELISA method. 24-hr recall was also assessed. All of participants completed the study. PGEdecreased significantly in both groups (p< .001), but there was no significant differences between groups. The results of this study indicated that intake of the selected herbs twice a day for 4 weeks may improve the PGElevels in patients with chronic knee osteoarthritis similar to Naproxen drug.

Print Options

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & receive The Dark Side of Wheat Ebook

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

The Dark Side of Wheat

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2023 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.