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Abstract Title:

Herbal Mixture ofL. Seed andAttenuates Amyloid Beta-Induced Cognitive Dysfunction In Vivo.

Abstract Source:

Foods. 2022 Jan 6 ;11(2). Epub 2022 Jan 6. PMID: 35053874

Abstract Author(s):

Meitong He, Jihyun Kim, Chanhum Park, Eunju Cho

Article Affiliation:

Meitong He

Abstract:

Deposition of amyloid-beta (Aβ) in the aging brain has been often observed and is thought to be a pathological feature of Alzheimer's disease. The use of natural products for disease prevention and treatment is gaining attention worldwide.L. seed andhave been used as traditional medicines in Asian countries, where they have been reported to exert anti-inflammatory and anti-oxidative effects. It has been demonstrated that the combination ofL. seed andhas an effect on cognitive enhancement, indicating a ratio of 5:5 synergistically enhancing learning and memory abilities in comparison with a single treatment. Here, we aimed to investigate the protective effect ofL. seed andmixture (CT) at different concentrations on cognition in Aβ-infused mice. CT-administered mice showed significant cognitive improvement in the T-maze, novel object recognition, and Morris water maze tests. Moreover, amyloidogenesis-related proteins, such asβ-secretase and γ-secretase, were detected and their protein levels decreased after treatment with CT. Our study shows that CT attenuates cognitive dysfunction by improving learning and memory capability and regulating Aβ-related proteins in Aβ-injected mice. These findings suggest that CT might be a candidate for functional food on cognitive improvement.

Study Type : Animal Study

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