Article Publish Status: FREE
Abstract Title:

Histopathologic Evaluation of Radio-Protective Effect of Hesperidin on the Liver of Sprague Dawely Rats.

Abstract Source:

J Biomed Phys Eng. 2020 Feb ;10(1):7-14. Epub 2020 Feb 1. PMID: 32158707

Abstract Author(s):

Ghorbani Zh, Fardid R, Haddadi G H, Derakhshanfar A, Kouhpayeh A, Haddadi Z

Article Affiliation:

Ghorbani Zh


Background: Hesperidin is a bioflavonoid glycoside mainly found in citrus fruit and has been shown radio-protective potential in various measurement systems.

Objective: In this article aims to investigate the radio-protective effect of hesperidin on the liver of Sprague Dawely rats.

Material and Methods: In this clinical study, 40 male rats were selected randomly and divided into 8 groups. Group 1 did not receive radiation and hesperidin (sham control). Group 2 received only 100 mg/kg body weight (b.w) of hesperidin for 7 consecutive days (HES group); group 3 exposed to dose of 2Gy whole body gamma radiation (2Gy group), and group 4 and 5 received 50 and 100 mg/kg b.w of HES for 7 consecutive days before 2 Gy gamma radiation, respectively.Group 6 exposed to dose of 8Gy gamma radiation (8Gy group); group 7 and 8 received 50 and 100 mg/kg b.w of HES for 7 days before 8Gy gamma irradiation, respectively. Histopathological evaluation was perfomred 24 hours after radiation.

Results: Administration of hesperidin (50 mg/kg b.w, 7 days) before 2Gy of gamma irradiation led to remove inflammatory mononuclear cells in the portal space. Microscopic findings in the groups receiving two doses of hesperidin (50 and 100 mg/kg b.w, orally, 7 days), before 8Gy of gamma radiation, were similar in a way that extreme dilation of central veins to be seen, however, there was no capillarization.

Conclusion: HES can be offered as a suitable radio-protector in radiotherapy patients and radiation workers.

Study Type : Animal Study
Additional Links
Diseases : Radiation
Pharmacological Actions : Radioprotective : CK(1668) : AC(521)

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