Abstract Title:

Neuroprotective effect of Hibiscus rosa sinensis in an oxidative stress model of cerebral post-ischemic reperfusion injury in rats.

Abstract Source:

Pharm Biol. 2010 Jul;48(7):822-7. PMID: 20645783

Abstract Author(s):

Vandana S Nade, Laxman A Kawale, Subhash Dwivedi, Adhikrao V Yadav

Article Affiliation:

M.V.P.S. College of Pharmacy, Gangapur Road, Shivaji Nagar, Nashik-422 002, Maharashtra, India. [email protected]


CONTEXT: The ischemic brain lesions induced in rats by temporary occlusion of the bilateral common carotid arteries and restoration of blood flow to an ischemic brain region is associated with generation of reactive oxygen species with consequent reperfusion injury. OBJECTIVE: The present study investigated the neuroprotective potential of Hibiscus rosa sinensis L. (Malvaceae) in a bilateral common carotid artery (BCCA) occlusion model of global cerebral ischemic reperfusion. MATERIALS AND METHODS: The animals underwent 30 min BCCA occlusion and 45 min reperfusion. The methanol extract of H. sinensis (100, 200, 300 mg/kg/day for 6 days, p.o.) was administered 30 min before induction of BCCA occlusion. RESULTS: The bilateral common carotid artery occlusion resulted in increase in lipid peroxidation, and reduction in superoxide dismutase (SOD), catalase (CAT) and glutathione reductase (GSH) activity. The extract attenuated the ischemic reperfusion-induced increase in lipid peroxidation and fall in SOD, CAT, and GSH levels. The cerebral hypoperfusion caused a propensity towards anxiety and was accompanied by deficits of learning and memory. The extract ameliorated anxiety and there was improvement of learning and memory. Discussion: The administration of H. sinensis prevented the oxidative stress and the biochemical changes associated with cerebral ischemic reperfusion injury. The mechanism of such protection of H. sinensis may be due to cerebral adaptation, through augmentation of cellular antioxidants such as GSH, SOD and CAT. The results suggest the protective role of H. sinensis in ischemic reperfusion injury. CONCLUSION: This study indicates the beneficial role of H. sinensis in cerebrovascular insufficiency states and dementia.

Study Type : Animal Study

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.