Abstract Title:

Magnesium stearate given perorally to rats. A short term study.

Abstract Source:

Toxicology. 1980;17(1):51-5. PMID: 7434368

Abstract Author(s):

D Søndergaard, O Meyer, G Würtzen


Magnesium stearate was fed to groups of 20 male and 20 female rats at levels of 0, 5, 10 and 20% in a semisynthetic diet for 3 months. Decreased weight gain was found in males in the 20% group. Urolithiasis was found in 8 males and in 7 females in the same group. Reduced relative liver weight was seen in males in the 10% and in the 20% groups, and an increased amount of iron was found in the livers of the 20% group. Nephrocalcinosis was reduced in females in the 20% group. In this experiment the no-effect-level is estimated to be 5% magnesium stearate in the diet, corresponding to 2500 mg/kg body wt/day.

Study Type : Animal Study
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