Abstract Title:

Cellular toxicity driven by high-dose vitamin C on normal and cancer stem cells.

Abstract Source:

Biochem Biophys Res Commun. 2018 02 26 ;497(1):347-353. Epub 2018 Feb 9. PMID: 29432735

Abstract Author(s):

Tae-Jun Kim, Jin-Seok Byun, Hyun Sook Kwon, Do-Yeon Kim

Article Affiliation:

Tae-Jun Kim


As a powerful antioxidant, vitamin C protects cells from oxidative damage by inhibiting production of free radicals. However, high levels of vitamin C shows cytotoxicity especially on cancerous cells through generating excessive ROS and blocking the energy homeostasis. Although the double-sided character of vitamin C has been extensively studied in many cell types, there is little research on the consequence of vitamin C treatment in stem cells. Here, we identified that high-dose vitamin C shows cellular toxicity on proliferating NSPCs. We also demonstrated that undifferentiated NSPCs are more sensitive to vitamin C-driven DNA damage than differentiated cells, due to higher expression of Glut genes. Finally, we showed that high-dose vitamin C selectively induces DNA damage on cancer stem cells rather than differentiated tumor cells, raising a possibility that vitamin C may be used to target cancer stem cells.

Study Type : In Vitro Study

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