Abstract Title:

High doses of atorvastatin (Sortis) modify the secretory process in the exocrine portion of the pancreas.

Abstract Source:

Ann Univ Mariae Curie Sklodowska Med. 2004 ;59(2):52-6. PMID: 16146048

Abstract Author(s):

Krystyna Czerny, Jadwiga Romanowska, Ewa Kifer-Wysocka, Włodzimierz Matysiak, Teresa Masłyk

Article Affiliation:

Department and Institute of Histology and Embryology, Skubiszewski Medical University of Lublin.


Changes were observed in the ultrastructure of the pancreatic acinar cells in rats after administration of atorvastatin (Sortis) in the therapeutic and ten times larger dose for the period of 6 weeks. It was found that atorvastatin given to rats in the therapeutic dose (80 mg/day) stimulated the secretion in pancreocytes, whereas the ten times higher dose of atorvastatin distorts the complicated process of the release of the secretion from the cell.

Study Type : Animal Study

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