Abstract Title:

Efficacy and Safety of Two Analogs of L-Carnitine on Rats Made Insulin Resistant by a High-Fructose Diet.

Abstract Source:

Pharmacology. 2011 Jun 25;88(1-2):10-17. Epub 2011 Jun 25. PMID: 21709430

Abstract Author(s):

Antonieta Gómez-Solís, Ricardo De la Cruz-Cordero, Anaguiven Avalos-Soriano, Miguel Angel Duarte-Vázquez, Jorge Reyes-Esparza, Lourdes Rodríguez-Fragoso

Article Affiliation:

Facultad de Farmacia, Universidad Autónoma del Estado de Morelos, Cuernavaca, Mexico.

Abstract:

Aim: To evaluate the efficacy and safety of 2 analogs of L-carnitine on rats made insulin resistant by a high-fructose diet. Methods: Using rats made insulin resistant by a high-fructose diet, we investigated the impact of 2 analogs of L-carnitine (25 mg/kg) and L-carnitine (250 mg/kg) on glucose, triglycerides and cholesterol blood levels, and liver glycogen. We also evaluated the safety of both analogs by the assessment of some biochemical and hematological parameters, a histological analysis and a study of embryotoxicity. Results: Both analogs reduced the levels of triglycerides in the liver and plasma, but only analog 2 reduced the cholesterol levels in insulin-resistant rats. No changes were observed in glycogen content. Safety evaluations revealed alterations in blood lymphocytes and embryotoxicity data. Conclusion: This study demonstrated that the 2 analogs maintain the pharmacological properties of L-carnitine but have a different efficacy, potency and toxicity.

Study Type : Animal Study

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