Article Publish Status: FREE
Abstract Title:

Dietary fiber intake is inversely associated with risk of pancreatic cancer: a meta-analysis.

Abstract Source:

Asia Pac J Clin Nutr. 2017 Jan ;26(1):89-96. PMID: 28049267

Abstract Author(s):

Qi-Qi Mao, Yi-Wei Lin, Hong Chen, Jie Qin, Xiang-Yi Zheng, Xin Xu, Li-Ping Xie

Article Affiliation:

Qi-Qi Mao


BACKGROUND AND OBJECTIVES: The association between fiber intake and pancreatic cancer risk is conflicting and poorly explored. The aim of study was to investigate the association between dietary fiber intake and the risk of pancreatic cancer by conducting a meta-analysis of epidemiological studies.

METHODS AND STUDY DESIGN: Systematic search of PubMed and Embase databases up to April 2015 were conducted to identify relevant studies. Adjusted odds ratios (ORs) were combined using random-effects models to assess the risk of pancreatic cancer when comparing extreme categories of fiber intake. Dose-response meta-analysis was performed for studies reporting categorical risk estimates for at least 3 exposure levels.

RESULTS: One cohort and thirteen case-control studies were identified. The overall analysis revealed a strong inverse association between risk of pancreatic cancer and high fiber intake (OR 0.52; 95% CI 0.44-0.61). No publication bias was detected by Egger's or Begg's test. The dose-response analyses showed that the summary OR for an increment of 10 g daily intake of fiber was 0.88 (0.84 to 0.92).

CONCLUSION: A high intake of dietary fiber was associated with a reduced risk of pancreatic cancer. Further well-designed prospective studies are warranted to confirm the inverse association and to identify the dietary fiber types involved.

Study Type : Meta Analysis

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Sayer Ji
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