Abstract Title:

Higher dietary intake of alpha-linolenic acid is associated with lower insulin resistance in middle-aged Japanese.

Abstract Source:

Prev Med. 2010 May-Jun;50(5-6):272-6. Epub 2010 Mar 4. PMID: 20211645

Abstract Author(s):

Takashi Muramatsu, Hiroshi Yatsuya, Hideaki Toyoshima, Satoshi Sasaki, Yuanying Li, Rei Otsuka, Keiko Wada, Yo Hotta, Hirotsugu Mitsuhashi, Kunihiro Matsushita, Toyoaki Murohara, Koji Tamakoshi

Article Affiliation:

Takashi Muramatsu


OBJECTIVE: To investigate the associations between dietary intake of n-3 polyunsaturated fatty acids (plant-derived alpha-linolenic acid: ALA, and marine-derived eicosapentaenoic and docosahexaenoic acid: EPA+DHA) and insulin resistance (IR) in a lean population with high n-3 PUFA intake.

METHOD: We cross-sectionally studied 3383 Japanese local government workers aged 35-66 in 2002. IR was defined as the highest quartile of homeostasis model assessment, and nutrient intake was estimated from a diet history questionnaire. The odds ratios (ORs) of IR taking the lowest quartile of ALA or EPA+DHA intake as the reference were calculated by logistic regression analysis.

RESULTS: Mean age, body mass index (BMI), and dietary ALA, and median of dietary EPA+DHA were 47.9 years, 22.9 kg/m(2), and 1.90 g/day (0.88%E) and 0.77 g/day (0.36%E), respectively. The ORs of IR decreased across the quartiles of ALA intake (multivariate-adjusted OR for Q4 versus Q1=0.74, P for trend=0.01) and the association was observed only in subjects with a BMI of<25 kg/m(2) (P for interaction=0.033). However EPA+DHA showed no such associations consistently.

CONCLUSION: Higher ALA intake was significantly associated with a lower prevalence of IR in normal weight individuals of middle-aged Japanese men and women.

Study Type : Human Study

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