Abstract Title:

Higher levels of objectively measured sedentary behavior is associated with worse cognitive ability: Two-year follow-up study in community-dwelling older adults.

Abstract Source:

Exp Gerontol. 2017 Sep 28 ;99:110-114. Epub 2017 Sep 28. PMID: 28962854

Abstract Author(s):

Po-Wen Ku, Yi-Te Liu, Ming-Kuei Lo, Li-Jung Chen, Brendon Stubbs

Article Affiliation:

Po-Wen Ku


BACKGROUND: A number of cross-sectional studies have suggested that higher levels of sedentary behavior (SB) are associated with worse cognitive abilities in older age. There is a paucity of longitudinal studies investigating this relationship utilizing objectively assessed SB. This study investigated the relationship between objectively assessed SB and future cognitive abilities in a cohort of older adults.

METHODS: A longitudinal study over 22.12±1.46months including 285 community-dwelling older adults across 14 regions in Taiwan was undertaken. Cognitive ability was ascertained using a Chinese version of the Ascertain Dementia 8-item Questionnaire (AD8) and SB captured by 7days accelerometer data. Multivariable negative binomial regression models adjusted for confounders were undertaken.

RESULTS: 274 community-dwelling older adults finished the study (age=74.6±6.2, % female=54.4%). At baseline, 20.1% (n=55), 48.5% (n=133) and 31.4% (n=86) of the sample engaged in high (11+h), medium (7-10.99h) and low (<7h) of SB respectively. In the fully adjusted model, higher levels of SB were associated with an increased risk of worse cognitive ability at follow up (adjusted rate ratio (ARR)1.09 (95%CI:1.00-1.19)), with the strongest relationship evident in those engaging in over 11h of SB (ARR 2.27 (95%CI:1.24-4.16)). The relationship remained evident after adjusting for depressive symptoms and physical activity.

CONCLUSION: Our data suggests that objectively assessed SB, particularly when over 11h a day, is independently associated with worse cognitive ability over a two year period. Our data adds to the pressing reasons to reduced SB in older age.

Study Type : Human Study

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