Urinary bisphenol A concentration and risk of central obesity in Chinese adults: a prospective study.
J Diabetes. 2017 Jan 18. Epub 2017 Jan 18. PMID: 28097815
BACKGROUND: Previous studies have associated bisphenol A (BPA) exposure with diabetes and related metabolic disorders such as obesity. Study regarding association of urinary BPA concentrations with central obesity risk is limited. We aimed to prospectively investigate the association of urinary BPA with incident central obesity in a Chinese population aged 40 years and above.
METHODS: 888 participants who were not central obese at baseline in 2009 were followed for 4 years in Shanghai, China. BPA concentrations were measured by baseline morning spot urine samples. Central obesity was defined as waist circumference of 90 cm or higher in men and 80 cm or higher in women.
RESULTS: During a mean follow-up of 4 years, 124 (14.0%) participants developed central obesity. Each 1-unit of log-BPA was positively associated with 2.30 folds of risk for incident central obesity (95% confidence interval [CI]: 1.39-3.78, P < 0.001) after adjustment for confounders. Compared with the lowest tertile of urinary BPA concentration, tertile 2 and 3 were associated with a higher risk of incident central obesity (odds ratio [OR] = 1.79, 95% CI: 1.08-2.97; OR = 1.83, 95% CI: 1.09-3.08, respectively). Stratified analysis showed that associations of BPA with incident central obesity were significant in women and individuals who were younger than 60 years, normal weight, non-smoker, non-drinker, or non-hypertensive.
CONCLUSIONS: Our results indicate that higher urinary BPA concentrations might associate with greater risk of incident central obesity in Chinese adults. It emphasizes the effect of BPA exposure on metabolic risk from a public health perspective.