Abstract Title:

Hippomanin A from acetone extract of Phyllanthus urinaria inhibited HSV-2 but not HSV-1 infection in vitro.

Abstract Source:

Phytother Res. 2007 Dec;21(12):1182-6. PMID: 17661333

Abstract Author(s):

Chien-Min Yang, Hua-Yew Cheng, Ta-Chen Lin, Lien-Chai Chiang, Chun-Ching Lin


Phyllanthus urinaria Linnea (Euphorbiaceae) is a commonly used traditional medicinal plant in oriental countries and has been reported to possess various biological activities. Previously, the acetone extract and some pure compounds from P. urinaria were found to suppress herpes simplex virus (HSV). In this study, another two pure compounds were isolated from acetone extract of P. urinaria and were tested for their in vitro anti-HSV-1 and HSV-2 activities. The results showed that hippomanin A impeded HSV-2 but not HSV-1 infection. Corilagin, however, inhibited neither HSV-1 nor HSV-2 replication. The similarity between corilagin and hippomanin A in structure, but difference in antiviral activity, therefore, merit further investigation. Copyright (c) 2007 John Wiley & Sons, Ltd.


Study Type : In Vitro Study

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