Article Publish Status: FREE
Abstract Title:

Antiproliferative activity of chloroformic extract of Persian Shallot, Allium hirtifolium, on tumor cell lines.

Abstract Source:

Cytotechnology. 2008 Mar ;56(3):179-85. Epub 2008 Apr 11. PMID: 19002856

Abstract Author(s):

Hamideh Ghodrati Azadi, Seyed Mahmood Ghaffari, Gholam Hossein Riazi, Shahin Ahmadian, Fatemeh Vahedi

Article Affiliation:

Hamideh Ghodrati Azadi


Allium hirtifolim (Persian Shallot) belongs to Allium genus (Alliaceae family). We investigated the in vitro effects of chloroformic extract of A. hirtifolium and its Allicin on the proliferation of HeLa (cervical cancer), MCF7 (human, caucasion, breast, adenocarcinoma) and L929 (mouse, C3H/An, connective) cell lines. Our results showed that components of A. hirtifolium might inhibit proliferation of tumor cell lines. This inhibition in HeLa and MCF-7 cells was dose-dependent. The presence of Allicin was evaluated by TLC method in bulbs and the extract of A. hirtifolium was analyzed by HPLC. MTT test was performed 24, 48 and 72 h after cell culture. A significant decrease in cell lines was observed in HeLa and MCF-7 as compared to L929 cell lines. DNA fragmentation analysis revealed a large number of apoptotic cells in treated HeLa and MCF-7 cell groups, but no effects in L929 cells. Therefore A. hirtifolium might be a candidate for tumor suppression.

Study Type : In Vitro Study

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