Article Publish Status: FREE
Abstract Title:

Home Exercise Training Improves Exercise Capacity in Cirrhosis Patients: Role of Exercise Adherence.

Abstract Source:

Sci Rep. 2018 01 8 ;8(1):99. Epub 2018 Jan 8. PMID: 29311671

Abstract Author(s):

Calvin Kruger, Margaret L McNeely, Robert J Bailey, Milad Yavari, Juan G Abraldes, Michelle Carbonneau, Kim Newnham, Vanessa DenHeyer, Mang Ma, Richard Thompson, Ian Paterson, Mark J Haykowsky, Puneeta Tandon

Article Affiliation:

Calvin Kruger


Cirrhosis patients have reduced peak aerobic power (peak VO) that is associated with reduced survival. Supervised exercise training increases exercise tolerance. The effect of home-based exercise training (HET) in cirrhosis is unknown. The objective was to evaluate the safety and efficacy of 8 weeks of HET on peak VO, 6-minute walk distance (6MWD), muscle mass, and quality of life in cirrhosis. Random assignment to 8 weeks of HET (moderate to high intensity cycling exercise, 3 days/week) or usual care. Exercise adherence defined as completing≥80% training sessions. Paired t-tests and analysis of covariance used for comparisons. Forty patients enrolled: 58% male, mean age 57 y, 70% Child Pugh-A. Between group increases in peak VO(1.7, 95% CI: -0.33 to 3.7 ml/kg/min, p = 0.09) and 6MWD (33.7, 95% CI: 5.1 to 62.4 m, p = 0.02) were greater after HET versus usual care. Improvements even more marked in adherent subjects for peak VO(2.8, 95% CI: 0.5-5.2 mL/kg/min, p = 0.02) and 6MWD (46.4, 95% CI: 12.4-80.5 m, p = 0.009). No adverse events occurred during testing or HET. Eight weeks of HET is a safe and effective intervention to improve exercise capacity in cirrhosis, with maximal benefits occurring in those who complete ≥80% of theprogram.

Study Type : Human Study
Additional Links
Therapeutic Actions : Exercise : CK(4855) : AC(736)

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