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Article Publish Status: FREE
Abstract Title:

Antidiabetic efficacy of a honey-royal jelly mixture: Biochemical study in rats.

Abstract Source:

Int J Health Sci (Qassim). 2021 Jul-Aug;15(4):4-9. PMID: 34285683

Abstract Author(s):

Sultan Fahad Al Nohair

Article Affiliation:

Sultan Fahad Al Nohair

Abstract:

Objectives: The current tools for the management of diabetes mellitus (DM) do not prevent its development or complications, so investigations into promising new treatments, for example, honey-royal jelly (H-RJ) mixtures, are needed. This study was conducted to evaluate the effect of royal jelly on DM by measuring the biochemical parameters (fasting blood glucose and glycated hemoglobin [HbA1c]) accompanying streptozotocin (i.p. 75 mg/kg once)-induced type 1 DM (T1DM) in rats. Other objectives were to evaluate the effects of H-RJ on lipid parameters.

Methods: Ten healthy control male Sprague-Dawley rats (120-150 g) were compared to untreated T1DM (= 10), metformin-treated T1DM (= 10), and H-RJ-treated T1DM rats (= 10) on plasma and whole-blood glycemic control indices (fasting blood glucose, HbA1c %, insulin, and insulin resistance) and plasma lipid profile (triglycerides [TGs] and total, low-density lipoprotein -, high-density lipoprotein -, and very low-density lipoprotein [VLDL]-cholesterol). Diabetes was induced by a single intraperitoneal injection of streptozotocin (SZT) at 75 mg/kg body weight (BW). The T1DM-H-RJ rat group received daily RJ (100 mg/kg BW). Parametric data are presented as mean± SD and were analyzed for comparison using one-way ANOVA in SPSS software.

Results: H-RJ normalized glycemic control indices, but its effect on lipid parameters was variable. H-RJ and metformin had comparable effects. The H-RJ treatment caused a significant reduction in plasma VLDL-C content in comparison to the control treatment and metformin. The limitation of this study is that it was restricted to T1DM and did not involve type 2 DM. In addition, the study was limited to male Sprague-Dawley rats, with no females.

Conclusion: The H-RJ mixture is a promising antidiabetic alternative medicine. It effectively reduces VLDL-C and TG in diabetic rats.

Study Type : Animal Study

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