Abstract Title:

[Effects of Honokiol on cognitive function in mice with kainic acid-induced epilepsy].

Abstract Source:

Zhejiang Da Xue Xue Bao Yi Xue Ban. 2018 May 25 ;47(5):450-456. PMID: 30693685

Abstract Author(s):

Qingmei Wang, Min Shu, Qianzi Xu, Yiyi Xie, Shengzhe Ruan, Jianda Wang, Linghui Zeng

Article Affiliation:

Qingmei Wang


OBJECTIVE: To investigate the effects of Honokiol on cognitive function in mice with epilepsy.

METHODS: Kainic acid (38 mg/kg) was intraperitoneally injected in 5 weeks old male ICR mice to induce epilepsy. Honokiol at dose of 3, 10, 30 mg/kg was given to epilepic mice by intraperitoneal injection for 10 days. Fluoro-Jade B staining was used to assess neuronal death; Morris water maze and Y maze tests were used to measure cognitive function such as learning and memory; Western blot was performed to detect the expression of acetylated superoxide dismutase (SOD), microtubule associated protein 1 light chain 3-Ⅱ (LC3-Ⅱ) and P62 in hippocampus tissue; thiobarbituric acid and WST-1 methods were used to detect malondialdehyde (MDA) and SOD.

RESULTS: Compared with control group, the levels of acetylated-SOD, MDA, LC3-Ⅱ, P62 and neuronal death increased, cognitive function and SOD decreased in model group (<0.05 or<0.01). Honokiol at the dose of 10 mg/kg and 30 mg/kg decreased SOD acetylation, MDA content, expression of LC3-Ⅱ and P62, as well as neuronal death, and the cognitive function was improved (<0.05 or<0.01), especially in 30 mg/kg Honokiol group.

CONCLUSIONS: Honokiol alleviates oxidative stress and autophagy degradation disorder, decreases neuronal death, and therefore improves cognitive function in epilepsy mice.

Study Type : Animal Study

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Sayer Ji
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