Article Publish Status: FREE
Abstract Title:

Oral Intake of Hydrangea serrata (Thunb.) Ser. Leaves Extract Improves Wrinkles, Hydration, Elasticity, Texture, and Roughness in Human Skin: A Randomized, Double-Blind, Placebo-Controlled Study.

Abstract Source:

Nutrients. 2020 May 28 ;12(6). Epub 2020 May 28. PMID: 32481760

Abstract Author(s):

Da-Bin Myung, Jeong-Hun Lee, Hee-Soo Han, Kwang-Young Lee, Hye Shin Ahn, Yu-Kyong Shin, Eunjung Song, Bo-Hyung Kim, Kwang Hoon Lee, Sun Hee Lee, Kyung-Tae Lee

Article Affiliation:

Da-Bin Myung


Previously, we reported that the hot water extract ofleaves (WHS) and its active component, hydrangenol, possess in vitro and in vivo effects on skin wrinkles and moisturization. We conducted a randomized, double-blind, placebo-controlled trial to clinically evaluate the effect of WHS on human skin. Participants (= 151) were randomly assigned to receive either WHS 300 mg, WHS 600 mg, or placebo, once daily for 12 weeks. Skin wrinkle, hydration, elasticity, texture, and roughness parameters were assessed at baseline and after 4, 8, and 12 weeks. Compared to the placebo, skin wrinkles were significantly reduced in both WHS groups after 8 and 12 weeks. In both WHS groups, five parameters (R1-R5) of skin wrinkles significantly improved and skin hydration was significantly enhanced when compared to the placebo group after 12 weeks. Compared with the placebo, three parameters of skin elasticity, including overall elasticity (R2), net elasticity (R5), and ratio of elastic recovery to total deformation (R7), improved after 12 weeks of oral WHS (600 mg) administration. Changes in skin texture and roughness were significantly reduced in both WHS groups. No WHS-related adverse reactions were reported. Hence, WHS could be used as a health supplement for skin anti-aging.

Study Type : Human Study

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