Abstract Title:

How microwave treatment of gluten affects its toxicity for celiac patients? A study on the effect of microwaves on the structure, conformation, functionality and immunogenicity of gluten.

Abstract Source:

Food Chem. 2019 Nov 1 ;297:124986. Epub 2019 Jun 11. PMID: 31253255

Abstract Author(s):

Hamida Mahroug, Miguel Ribeiro, Larbi Rhazi, Leila Bentallah, Mohammed Nasreddine Zidoune, Fernando M Nunes, Gilberto Igrejas

Article Affiliation:

Hamida Mahroug


The microwave heating of wheat kernels, flour, and gluten, has attracted attention lately because it has been claimed to abolish gluten toxicity for celiac patients. Nevertheless, contradictory results have been reported regarding the effect on gluten celiac-immunotoxicity. In order to better understand the effect of the microwave treatment on gluten structure, conformation, functionality and celiac-immunotoxicity, a central composite design with two factors, power level, and treatment time, was used to investigate a possible quadratic and interaction effects between both factors. Extractable gliadins content was affected by the power and time in a linear and quadratic fashion; extractable glutenins were not affected. Gluten secondary structure was affected by the microwave treatment and related to the polymer's disaggregation phenomenon observed. In fact, the microwave treatment increased the amount of potentially toxic epitopes released after peptic and tryptic digestion, showing inefficiency as a treatment to detoxify the gluten for celiac disease patients.

Study Type : In Vitro Study

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