Article Publish Status: FREE
Abstract Title:

Huaier aqueous extract inhibits colorectal cancer stem cell growth partially via downregulation of the Wnt/β-catenin pathway.

Abstract Source:

Oncol Lett. 2013 Apr ;5(4):1171-1176. Epub 2013 Jan 21. PMID: 23599758

Abstract Author(s):

Tao Zhang, Ke Wang, Junshu Zhang, Xiaolei Wang, Zhigang Chen, Chao Ni, Fuming Qiu, Jian Huang

Article Affiliation:

Tao Zhang

Abstract:

The existence of cancer stem cells (CSCs) is central to the pathogenesis and therapy resistance of colorectal cancer. The aim of this study was to evaluate whether Huaier aqueous extract, a Chinese medicine, has efficacy against CSCs and to investigate the mechanisms of its anticancer effects. It was observed that the Huaier extract significantly inhibited the spheroid formation potential (P<0.05) and decreased the aldehyde dehydrogenase (ALDH)-positive cell population in colorectal primary cancer cells (P<0.05). Western blotting analysis and Wnt/β-catenin reporter assays revealed that the Huaier extract downregulated the Wnt/β-catenin self-renewal pathway. This is the first study to demonstrate that Huaier aqueous extract acts as an effective agent for eradicating colorectal CSCs and identifies the Wnt/β-catenin pathway as its potentialtarget, which may be a new approach for colorectal cancer therapy.

Study Type : In Vitro Study

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Sayer Ji
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