Abstract Title:

Hydroxychavicol: a potent xanthine oxidase inhibitor obtained from the leaves of betel, Piper betle.

Abstract Source:

J Nat Med. 2009 Jul ;63(3):355-9. Epub 2009 Apr 22. PMID: 19387769

Abstract Author(s):

Kazuya Murata, Kikuyo Nakao, Noriko Hirata, Kensuke Namba, Takao Nomi, Yoshihisa Kitamura, Kenzo Moriyama, Takahiro Shintani, Munekazu Iinuma, Hideaki Matsuda

Article Affiliation:

Kazuya Murata


The screening of Piperaceous plants for xanthine oxidase inhibitory activity revealed that the extract of the leaves of Piper betle possesses potent activity. Activity-guided purification led us to obtain hydroxychavicol as an active principle. Hydroxychavicol is a more potent xanthine oxidase inhibitor than allopurinol, which is clinically used for the treatment of hyperuricemia.

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