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Article Publish Status: FREE
Abstract Title:

Icariin and its metabolites as potential protective phytochemicals against cardiovascular disease: From effects to molecular mechanisms.

Abstract Source:

Biomed Pharmacother. 2022 Mar ;147:112642. Epub 2022 Jan 21. PMID: 35078094

Abstract Author(s):

Yufei Zeng, Yilin Xiong, Tao Yang, Yan Wang, Jing Zeng, Shaoyu Zhou, Yunmei Luo, Lisheng Li

Article Affiliation:

Yufei Zeng

Abstract:

Cardiovascular disease (CVD) is the leading cause of morbidity and mortality among all types of diseases in the world, affecting many millions of individuals every year. CVD includes hypertension, atherosclerosis, pulmonary hypertension, heart failure, cardiomyopathy, coronary heart disease, etc., which are involved in complex etiology, pathogenesis and many risk factors. Modern pharmacological studies have revealed that Epimedium possesses a variety of beneficial effects in regulating cardiovascular inflammation and other biological activities, which provides a therapeutic value for the prevention and treatment of these cardiovascular diseases. In this review, we discuss the cardiovascular protective effects of icariin, an active component from Epimedium, and its metabolites. We summarize a range of studies showing that the modes of action of icariin on CVD relate to its inhibition of myocardial apoptosis and prevention of inflammation on endothelial cell injury, emphasizing the multiple effects of icariin and its metabolites in the repair of common heart failure and myocardial infarction, as well as the formation of neointima. In particular, an emphasis is placed on the discussion of the action mechanism of icariin in combination with new advances in the understanding of the pathology of CVD with potential application of icariin in the treatment of this human disorder.

Study Type : Review

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