Abstract Title:

Identification ofα-Amylase and α-Glucosidase Inhibitors and Ligularoside A, a New Triterpenoid Saponin fromJuss (Sweet Granadilla) Leaves, by a Nuclear Magnetic Resonance-Based Metabolomic Study.

Abstract Source:

J Agric Food Chem. 2021 Mar 10 ;69(9):2919-2931. Epub 2021 Feb 23. PMID: 33621072

Abstract Author(s):

Gabriel Monzón Daza, Carolina Meneses Macías, Abel M Forero, Jaime Rodríguez, Marcela Aragón, Carlos Jiménez, Freddy A Ramos, Leonardo Castellanos

Article Affiliation:

Gabriel Monzón Daza


The leaves ofJuss (known as sweet granadilla for its edible fruits) are a crop byproduct that is discarded. With the aim of contributing to give value-added products from these crop by-side products to farmers of Colombian Andes, we carried out aH-NMR-metabolomics analysis of polar extracts from leaves collected in three locations and stored in two conditions in order to identify glucosyl-hydrolase inhibitors. Variations in the metabolic profile and the bioactivity among samples were analyzed by orthogonal partial least square discriminant analysis. Thus,H-NMR signals related to polyphenolic compounds, saponins, and amino acids were correlated with higher inhibitory activities. Moreover, a targeted NMR and HPLC-MS/MS analysis allowed the identification of 14 polyphenolic compounds and the structural characterization of a new triterpenoid saponin, ligularoside A. The measurements of ICvalues forα-amylase and α-glycosidase inhibitors allowed the identification of quercetin-3--β-glucoside, kaempferol-3--β-glucoside, and ligularoside A as the most active compounds. These results suggest thatleaves are a source of glucosyl-hydrolase inhibitors and lay the foundation for exploring additional applications.

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